Prof. Yueling ZHANG
Ph.D. (Xiamen University, 2003)
Dean of College of Science
Professor in Marine Biology of Shantou University
Tel.: +86-754-86502580
E-mail:zhangyl@stu.edu.cn
EDUCATION
1991-1995 B.Sc., Biological Education, Xiangtan Normal University, China
1998-2003 Ph.D. Zoology, Xiamen University,China
EMPLOYMENT
1995.07-1998.08, Assistant Professor, Department of Biology, Xiangtan Normal University
2003.10-2005.09, Biology/Guangdong Provincial Key Laboratory of Marine Biotechnology, College of Science, Shantou University, Lecturer
2005.09-2009.12, Associate Professor, Biology/Guangdong Provincial Key Laboratory of Marine Biotechnology, College of Science, Shantou University
2009.12-2013.03, Key Laboratory of Biology/Marine Biotechnology of Guangdong Province, College of Science, Shantou University, Professor
2013.03-2014.03, Department of Biology, Uppsala University, Sweden, Visiting scholar
2014.03-present, Shantou University, College of Science/Guangdong Provincial Key Laboratory of Marine Biotechnology, Professor
COURSES TAKEN
Undergraduate: Biochemistry (II), Molecular immunology and its research technology, Advances in Marine life science.
Master's Degree: Advances in life science, advanced biochemistry and its research progress, modern molecular biology and its research progress, post-genomics, molecular immunology and its research technology, immunology technology and its application in aquaculture, aquatic animal diseases and immunity.
PhD: Advances in molecular immunology of Marine animals and Crustaceans
RESEARCH INTERESTS
Marine biomolecular immunology and proteomics
Immunity and diseases of aquatic animals
Representative projects:
1. National Natural Science Foundation of China: Molecular Mechanism and immunological significance of acetylation of hemocyanin in shrimp (No.31872596, 2019.1-2022.12, 610,000 yuan);
2. National Natural Science Foundation of China (NSFC) : Research on the molecular mechanism of Prawn hemocyanin regulating important immune signaling Pathways (No.31672689, 2017.1 ~ 2018.12, 250,000 Yuan);
3. National Natural Science Foundation of China (NSFC) : Formation mechanism and immunological significance of functional degradation fragments of Hemocyanin in shrimp (No.31372558, 2014.1 ~ 2017.12, 800,000 yuan);
4. National Natural Science Foundation of China (NSFC) : Study on the molecular mechanism of Functional Diversity of Hemocyanin in Prawn (No.31072237, 2011.1 ~ 2013.12, 350,000 yuan);
5. National Natural Science Foundation of China (NSFC) : Study on the molecular mechanism of bacteriostasis of Hemocyanin of Prawn (No.30871939, 2009.1 ~ 2011.12, RMB 280,000);
6. Key project of Natural Science Foundation of Guangdong Province: Study on the formation of phosphorylation and immune regulation mechanism of hemocyanin in shrimp (2017A030311032, 2017.5 ~ 2020.5, 500,000 yuan);
7. Key project of Natural Science Foundation of Guangdong Province: Study on molecular polymorphism of hemocyanin of Prawn (No. 10251503101000002,2010.10 ~ 2013.9, 200,000 Yuan);
8. Provincial Major research Project of Universities in Guangdong Province: Study on the function and regulatory mechanism of Notch signaling pathway in shrimp infection with WSSV (No.2017KZDXM033, 2018.1 ~ 2020.12, 250,000 yuan);
9. Key Project of Science and Technology Innovation in Universities of Guangdong Province: Research on disease-resistant and degraded fragments of Penaeus haemocyanin (No.2012CXZD0025, 2012.1-2014.12, 300,000 yuan);
10. Major Scientific Research Projects in Universities of Guangdong Province - National Major Cultivation Projects: Molecular Network Research on Immune regulation of Shrimp Hemocyanin (No. 2014GKXM043, 2014.1-2016.12, 700,000 yuan)
11. Li Ka-shing Foundation Cross-research Project: Study on the homeostasis regulation mechanism of Blood flora based on Crustacean Model (No. 2020LKSFG01E, 2020.7 ~ 2023.6, 3 million yuan);
12. Guangdong Science and Technology Project: Application and promotion of healthy aquaculture and efficient pollution-free aquaculture industry model (2019.1 ~ 2019.12, 100,000 yuan);
13. Guangdong Science and Technology Plan Project: Sub-project of Collaborative Innovation Promotion Project of Jieyang Aquaculture Industry (No. 2017B020245001, 2017.7 ~ 2019.6, 150,000 yuan).
Representative publications:
Note：first/joint first, corresponding/joint corresponding author, * denotes corresponding author, # joint first, Zhang YL is Zhang Yueling
1.Liu SJ, Aweya JJ, Zheng LY, Zheng Z, Huang H, Wang F, Yao DF, Ou T*, Zhang YL*. LvHemB1, a novel cationic antimicrobial peptide derived from the hemocyanin of Litopenaeus vannamei, induces cancer cell death by targeting mitochondrial voltage-dependent anion channel 1. Cell Biology and Toxicology, 2021. https://doi.org/10.1007/s10565-021-09588-y.
2.Zheng Z, Li RW, Aweya JJ, Yao DF, Wang F, Li SK, Tuan TN, Zhang YL*. The PirB toxin protein from Vibrio parahaemolyticus induces apoptosis in hemocytes of Penaeus vannamei. Virulence, 2021, 12:1, 481-492.
3.Zhao WL, Zheng ZH, Aweya JJ, Wang F, Li SK, Tuan TN, Yao DF*, Zhang YL*. Litopenaeus vannamei Notch interacts with COP9 signalosome complex subunit 1 (CNS1) to negatively regulate the NF-κB pathway. Journal of Proteomics, 2021, 232:104074.
4.Yang S, Huang H, Aweya JJ, Zheng ZH, Liu GM, Zhang YL*. PvHS9 is a novel in silico predicted antimicrobial peptide derived from hemocyanin of Penaeus vannamei. Aquaculture, 2021, 530: 735926.
5.Huang ZS, Aweya JJ*, Zhu CH, Tran NT, Hong YJ, Li SK, Yao DF, Zhang YL*. Modulation of crustacean innate immune response by amino acids and their metabolites: inferences from other species. Frontiers in Immunology, 2020, 11: 574721.
6.Aweya JJ, Zheng XY, Zheng ZH, Wang W, Fan JH, Yao DF, Li SK, Zhang YL*. The sterol regulatory element binding protein homolog of Penaeus vannamei modulates fatty acid metabolism and immune response. Biochimica et Biophysica Acta- Molecular and Cell Biology of Lipids, 2020, 1865: 158757.
7.Yang S, Dong YT, Aweya JJ, Li J, Chen XY, Zhang YL*, Liu GM*. A hemoglobin-derived antimicrobial peptide, LCH4, from the large yellow croaker (Larimichthys crocea) with potential use as a food preservative. LWT - Food Science and Technology, 2020, 131 : 109656
8.Yang S, Dong YT, Juventus Aweya JJ, Xie TY, Zeng BB, Zhang YL*, Liu GM. Antimicrobial activity and acting mechanism of Tegillarca granosa hemoglobin-derived peptide (TGH1) against Vibrio parahaemolyticus. Microbial Pathogenesis, 2020, 147: 104302
9.Zhao MM, Yao DF, Li SK, Zhang YL*, Aweya JJ*. Effects of ammonia on shrimp physiology and immunity: a review. Reviews in Aquaculture, 2020, 1-18. doi: 10.1111/raq.12429.
10.Yang PK ,Juventus Aweya JJ, Yao DF,Wang F, Lun JS, Hong YJ, Sun KH, Zhang YL*. The krüppel-like factor of Penaeus vannamei negatively regulates transcription of the small subunit hemocyanin gene as part of shrimp immune response. Fish & Shellfish Immunology, 2020, 100: 397-406.
11.Zhang ZX, Yao DF, Yang PK, Zheng ZH, Aweya JJ, Lun JS, Hongyu Ma HY, Zhang YL*. Nuclear receptor E75 is a transcription suppressor of the Litopenaeus vannamei small subunit hemocyanin gene. Developmental and Comparative Immunology, 2020, 107: 103662.
12.Bao SY, Zheng ZH, Aweya JJ, Yao DF, Li SK, Sun CH, Hong YJ, Zhang YL*. microRNA-589-5p modulates the expression of hemocyanin as part of the anti-WSSV immune response in Litopenaeus vannamei. Developmental and Comparative Immunology，2020, 107: 103642.
13.Nie JJ, Yu ZX, Yao DF, Wang F, Zhu CH, Sun KH, Aweya JJ*, Zhang YL*. Litopenaeus vannamei sirtuin 6 homolog (LvSIRT6) is involved in immune response by modulating hemocytes ROS production and apoptosis. Fish & Shellfish Immunology, 2020, 98: 271-284.
14.Feng Q, Huang YQ, Yao DF, Zhu CH, Li SK, Ma HY, Aweya JJ*, Zhang YL*. Litopenaeus vannamei CK2 is involved in shrimp innate immunity by modulating hemocytes apoptosis. Fish & Shellfish Immunology, 2019, 94: 643-653.
15.Wei MH＃, Zhang YL＃, Aweya JJ, Wang F, Li SK, Lun JS, Zhu CH, Yao DF*. Litopenaeus vannamei Src64B restricts white spot syndrome virus replication by modulating apoptosis. Fish & Shellfish Immunology, 2019, 93: 313-321.
16.Gao GC, Lin RH, Tao MY, Aweya JJ, Yao DF, Ma HY, Li SK, Zhang YL*, Wang F*. Molecular characterization of a novel white spot syndrome virus response protein (dubbed LvWRP) from Litopenaeus vannamei. Developmental and Comparative Immunology，2019, 98: 99-107.
17.Fan JH, Li XM, Lu H, Lin RH, Aweya JJ, Aweya JJ*, Zhang YL*. N-terminal diversity of Litopenaeus vannamei hemocyanin and immunity. Molecular Immunology, 2019, 112, 360-368.
18.Yao DF, Liu YF, Chen XL, Lim TK, Wang LL, Aweya JJ, Zhang YL*, Lin QS*. In depth proteomic profling of the Singapore grouper iridovirus virion. Archives of Virology, 2019, 164, 1889-1895.
19.Yao DF, Wang ZH, Wei MH, Zhao XL, Aweya JJ, Zhong MQ, Li SK, Zhang YL*. Analysis of Litopenaeus vannamei hemocyanin interacting proteins reveals its role in hemolymph clotting. Journal of Proteomics. 2019, 201, 57-64.
20.Zhang ZH, Li RW, Aweya JJ, Wang F, Zhong MQ, Zhang YL*. Identification and characterization of glycosylation sites on Litopenaeus vannamei hemocyanin. FEBS Letters, 2019, 593(8), 820-830.
21.Wang W, Aweya JJ, Su HM, Zhao XL, Zhong MQ, Zhang YL*. Identification and immune-related analysis of SNPs in Litopenaeus vannamei Toll3 receptor. Immunology Letters, 2019, 206: 19–27.
22.Yang PK, Yao DF, Aweya JJ ,Wang F, Ning P, Li SK, Ma HY, Zhang YL*. c-Jun regulates the promoter of small subunit hemocyanin gene of Litopenaeus vannamei. Fish & Shellfish Immunology, 2019, 84: 639-647.
23.Zhan SX, Aweya JJ, Wang F, Yao DF, Zhong MQ, Chen JH, Li SK, Zhang YL*. Litopenaeus vannamei attenuates white spot syndrome virus replication by specific antiviral peptides generated from hemocyanin. Developmental and Comparative Immunology，2019, 91: 50-61.
24.Liu SJ, Aweya JJ, Zheng LY, Wang F, Zheng Z, Zhong MQ, Lun JS, Zhang YL*. A Litopenaeus vannamei hemocyanin-derived antimicrobial peptide (Peptide B11) attenuates cancer cells' proliferation. Molecules, 2018, 23, 3202.
25.Zhao WL, Yu ZX, Aweya JJ, Wang F, Yao DF, Ma HY, Lun JS, Zhang YL*. Molecular cloning and functional characterization of a homolog of the transcriptional regulator CSL in Litopenaeus vannamei. Developmental and Comparative Immunology，2018, 88: 152-160.
26.Zheng Z, Xu W, Aweya1 JJ, Zhong MQ, Liu SJ,Lun JS, Chen JH, Zhang YL*.Functional domains of Litopenaeus vannamei transglutaminase and their involvement in immunoregulation in shrimp. Fish & Shellfish Immunology, 2018, 81: 168-175.
27.Yang S, Huang H, Wang F, Aweya JJ, Zheng ZH, Zhang YL*. Prediction and characterization of a novel hemocyanin derived antimicrobial peptide from shrimp Litopenaeus vannamei. Amino Acids, 2018,50:995-1005.
28.Zhang YL, Gao GC, Lin RH, Aweya JJ, Tao MY, Wang F*. Transcriptome analyses reveal Litopenaeus vannamei hemocytes response to lipopolysaccharide. Fish & Shellfish Immunology, 2018, 76: 187-195.
29.Zheng ZH, Aweya JJ, Wang F, Yao DF, Lun JS, Li SK, Ma HY, Zhang YL*. Acute Hepatopancreatic Necrosis Disease (AHPND) related microRNAs in Litopenaeus vannamei infected with AHPND-causing strain of Vibrio parahemolyticus. BMC Genomics, 2018, 19:335.
30.Zheng ZH, Wang F, Aweya JJ, Li RW, Yao DF, Zhong MQ, Li SK, Zhang YL*. Comparative transcriptomic analysis of shrimp hemocytes in response to acute hepatopancreas necrosis disease (AHPND) causing Vibrio parahemolyticus infection. Fish & Shellfish Immunology, 2018, 74: 10-18.
31.Ning P, Zheng ZH, Aweya JJ, Yao DF, Li SK, Ma HY, Wang F, Zhang YL*. Litopenaeus vannamei notch affects lipopolysaccharides induced reactive oxygen species. Developmental and Comparative Immunology，2018, 81: 74-82.
32.Yao DF , Su HM , Zhu JH, Zhao XL, Aweya JJ, Wang F, Zhong MQ, Zhang YL*. SNPs in the Toll1 receptor of Litopenaeus vannamei are associated with immune response. Fish & Shellfish Immunology, 2018, 72: 410-417.
33.Li CP, Wang F, Aweya JJ, Yao DF, Zheng Z, Huang H, Li SK*, Zhang YL*. Trypsin of Litopenaeus vannamei is required for the generation of hemocyanin-derived peptides. Developmental and Comparative Immunology, 2018, 79: 95-104.
34.Zhang ZH, Wang F, Chen CD, Zheng Z, Aweya JJ, Zhang YL*. Glycosylation of hemocyanin in Litopenaeus vannamei is an antibacterial response feature. Immunology Letters, 2017, 192: 42–47.
35.Liu SJ, Zheng LY, Aweya JJ, Zheng Z, Zhong MQ, Chen JH, Wang F*, Zhang YL*. Litopenaeus vannamei hemocyanin exhibits antitumor activity in S180 mouse model in vivo. PLoS ONE, 2017, 12(8): e0183783.
36.Zhang YL, Peng B, Li H, Yan F, Wu HK, Zhao XL, Lin XM, Min SY,Gao YY, Wang SY, Li YY, Peng XX*. C-terminal domain of hemocyanin, a major antimicrobial protein from Litopenaeus vannamei: structural homology with immunoglobulins and molecular diversity. Frontiers in Immunology, 2017, 8: 611. doi: 10.3389/ fimmu.2017.00611.
37.Sun WW, Zhang XX, Wan WS, Wang SQ, Wen XB, Zheng HP, Zhang YL*, Li SK*.Tumor necrosis factor receptor-associated factor 6 (TRAF6) participates in anti-lipopolysaccharide factors (ALFs) gene expression in mud crab. Developmental ＆ Comparative Immunology, 2017, 67:361-376.
38.Liu P, Chen Y, Wang D, Tang YQ, Tang HQ, Song HC, Sun Q, Zhang YL*, Liu Z*. Genetic selection of peptide aptamers that interact and inhibit both small protein B and alternative ribosome-rescue factor A of Aeromonas veronii C4. Frontiers in Microbiology, 2016, 7: 1228.
39.Wen Y , Zhan SX , Huang H, Zhong MQ, Chen JH, You CH, Wang F**, Zhang YL*. Identification and characterization of an 18.4kDa antimicrobial truncation from shrimp Litopenaeus vannamei hemocyanin upon Vibrio parahaemolyticus infection. Fish & Shellfish Immunology, 2016, 56: 450 - 458.
40.Zhao XL, Guo LL, Lu X, Lu H, Wang F, Zhong MQ, Chen JH, Zhang YL*. Evidences of abundant hemocyanin variants in shrimp Litopenaeus vannamei. Molecular Immunology, 2016, 77: 103-112
41.Zheng LY, Zhao XL, Zhang P, Chen CD, Liu SJ, Huang RQ, Zhong MQ, Wei CJ, Zhang YL*. Hemocyanin from shrimp Litopenaeus vannamei has antiproliferative effect against HeLa cell in Vitro. PLoS ONE, 2016, 11(3): e0151801.
42.Lu X, Lu H, Guo LL, Zhang ZH, Zhao XL, Zhong MQ, Li SK, Zhang YL*. Cloning and characterization of a novel hemocyanin variant LvHMCV4 from shrimp Litopenaeus vannamei. Fish & Shellfish Immunology, 2015, 46（2）: 398 - 405.
43.Min SY, Yan F, Zhang YL*, Ye XQ, Zhong MQ, Cao JS, Zou HY, Chen JH. Characterization of a novel hemolytic activity of human IgG fractions arising from diversity in protein and oligosaccharide components. PLoS ONE，2014，9(1): e85711.
44.Cao JS, Wang ZH, Zhang YL*, Qu FL, Guo LL, Zhong MQ, Li SK, Zou HY, Chen JH, Wang XY. Identification and characterization of the related immune-enhancing proteins in crab Scylla paramamosain stimulated with rhubarb polysaccharides. Molecular Immunology, 2014, 57（2）: 263-273.
45.Wu HJ, Sun LB, Li CB, Li ZZ, Zhang Z, Wen XB, Hu Z, Zhang YL*, Li SK*. Enhancement of the immune response and protection against Vibrio parahaemolyticus by indigenous probiotic Bacillus strains in mud crab (Scylla paramamosain). Fish & Shellfish Immunology, 2014, 41:156-162.
46.Guo LL, Zhao XL , Zhang YL*, Wang ZH, Zhong MQ, Li SK, Lun JS. Evidences of SNPs in the variable region of hemocyanin Ig-like domain in shrimp Litopenaeus vannamei. Fish & Shellfish Immunology, 2013, 35（5）: 1532-1538.
47.Zhao S, Lu X , Zhang YL*, Zhao XL, Zhong MQ, Li SK, Lun JS. Identification of a novel alternative splicing variant of hemocyanin from shrimp Litopenaeus vannamei. Immunology Letters, 2013, 154(1-2):1-6.
48.Cao JS, Lin ZY, Zhang YL*, Zhang XY, Li SK, Zhang N, Zou WH, Li YY, Chen JH, Wang XY. Cloning and characterization of the SpLRR cDNA from green mud crab, Scylla paramamosain. Fish & Shellfish Immunology, 2013, 34(1): 129-135.
49.Lin ZY, Qiao J, Zhang YL*, Guo LL, Huang H, Yan F, Li YY, Wang XY. Cloning and characterisation of the SpToll gene from green mud crab, Scylla paramamosain Developmental ＆ Comparative Immunology, 2012, 37 (1): 164-175.
50.Zhao XL, Guo LL, Zhang YL*, Liu Y, Zhang XY, Lun JS, Chen JH, Li YY. SNPs of hemocyanin C-terminal fragment in shrimp Litopenaeus vannamei. FEBS Letters, 2012, 586 (4): 403-410.
51.Yan F，Zhang YL*, Jiang RP, Zhong MQ, Hu Z, Du H, Lun JS, Chen JH, Li YY*. Identification and agglutination properties of hemocyanin from the mud crab (Scylla serrata). Fish & Shellfish Immunology, 2011, 30（1）: 354-360.
52.Qiao J, Du ZH, Zhang YL*, Du H, Guo LL, Zhong MQ, Cao JS, Wang XY. Proteomic identification of the related immune-enhancing proteins in shrimp Litopenaeus vannamei stimulated with vitamin C and Chinese herbs. Fish & Shellfish Immunology, 2011, 31（6）, 736-745.
53.Yan F, Qiao J, Zhang YL*，Zhou N, Liu Y, Guo LL, Li YY, Chen JH. Hemolytic properties of hemocyanin from mud crab Scylla serrata. Journal of Shellfish Research, 2011, 30 (3): 957-962.
