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Report TitleBiosynthesis of Loline Alkaloids

Abstract:The fungal secondary metabolites, the loline alkaloids, feature a 1-aminopyrrolizidine ring with an unusual strained ether bridge connecting C(2) and C(7). I will discuss what we have learned about the biosynthetic pathway leading to these compounds and the enzymes that catalyze the biosynthetic steps.

Report time2015-6-5(Fri.)3:30 - 5:00 pm

Report place:ACC 5# meeting room

Reporter:Prof. Robert B. Grossman,Department of Chemistry,University of Kentucky

Reporter summary:

Education A.B. in Chemistry, Certificate of Proficiency in History of Science, Princeton University, Princeton, NJ, 1987

Ph.D., Massachusetts Institute of Technology, Cambridge, MA, 1992

Professional Experience

Summer Undergraduate Research Fellow, Allied-Signal Corp., Morristown, NJ, 1986

Graduate Teaching Assistant, Massachusetts Institute of Technology, 1987

Graduate Research Assistant, Massachusetts Institute of Technology, 1988-92

Postdoctoral Fellow, Massachusetts Institute of Technology, June-July 1992

Postdoctoral Fellow, Cambridge University, Cambridge, England, 1992-93

Research Associate, Cambridge University, Cambridge, England, 1993-94

Assistant Professor, University of Kentucky, 1994-2000

Associate Professor, University of Kentucky, 2000-2004

Professor, University of Kentucky, 2004-present

Director of Graduate Studies, 2006-2009

Current Research Interests

Organic Synthetic Methodology

Asymmetric Synthesis

Natural Products Synthesis

Chemical Ecology

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