STU-GTIIT光学论坛（No.20）
报告题目: Single-Heat-Source Genotyping by Fluorescent Quantitation of Integrated Lab-on-a-Chip Platform（全英报告）
报 告 人：Wenming Wu (The University of Chinese Academy of Sciences)
报告地点：at Room 202 in the building of college of science, STU
报告时间：2024年5月7日 17:00
报告摘要:
The Lab-on-a-Chip (LOC) technology is hailed as the most successful cutting-edge interdisciplinary field over the past three decades. This lecture will primarily focus on the conception and development of the LOC field, its essential functional components, and in situ detection instruments based on opto-mechatronics integration, particularly those geared towards point-of-care medical diagnostic devices. Traditional digital PCR platforms [1,2] can be broadly categorized into two main types in terms of workflow: flow-based (Bio-Rad) and array-based (ABI). Both rely on microfluidic chips to disperse droplets and require Peltier semiconductor modules along with H-bridge control circuitry for temperature regulation. We propose the "Constant Temperature Single Heat Source Model" to achieve temperature cycling in digital PCR, as well as an "Unprocessed Chip" approach for droplet formation, dispersion, and control. Additionally, we have developed a novel "Gas Diffusion Self-Driven Micro Pump" technology [3] to enable long-range, stable droplet transport without external energy input. These innovations not only reduce chip costs and instrument power consumption but also enhance portability [4] , meeting the requirements for use by non-specialist personnel.
[1] Kangning Wang, Limin He, Andreas Manz, Wenming Wu*, 2021, ANALYTICAL CHEMISTRY, 93, 3, 1523–1528.
[2] Yangyang Jiang, Andreas Manz and Wenming Wu*， Analytica Chimica Acta, 2020，ACA-20-374R2.
[3] Bing Shi, Di Wu and Wenming Wu*，2020，Advanced Materials Interfaces (admi.202001074R1) .
[4] Shuang Ma, Kangning Wang and Wenming Wu*， Analytica Chimica Acta, 2022，1229, 340338.
欢迎全校师生参加！
理学院
2024年4月28日
