I. BRIEF INTRODUCTION

Prof. Fan Wang

Ph.D. (National University of Singapore)

Tel: 86502720

E-mail: wangfan@stu.edu.cn

Educational Background:

PhD from January 2004 to October 2008, National University of Singapore

Master's degree from September 2000 to January 2003, Tsinghua University

Bachelor's degree from September 1996 to July 2000, Tsinghua University

Work Experience:

Professor January 2023 present Shantou University

Associate Professor from February 2016 to December 2022 at Shantou University

Postdoctoral Fellow, National University of Singapore, November 2008 to January 2015

II.REASEARCH

Main Research Interests:

Cell immunology of crustaceans

Projects Undertaken:

[1] Research on the Mechanism of Blimp1 Regulation on the Immune Activity of Shrimp Macrophages under the General Project of National Natural Science Foundation of China; (Number: 32373169), from January 2024 to December 2027-12, 500000.

[2] Research on the function and mechanism of shrimp neurotrophic factor MANF in inflammation regulation under the National Natural Science Foundation General Project; (Number: 41976123), from January 2020 to December 2023, 600000.

[3] Functional study on phosphorylation of major capsid proteins of iridovirus in virus assembly funded by Guangdong Natural Science Foundation; (Number: 2017A030307016), from May 2017 to May 2020, 100000.

[4] Guangdong Province Talent Project 2016 Sail Plan to Introduce Shortage Top notch Talents Project; From January 2017 to December 2019, there were 1 million.

[5] Research on shrimp immune factors based on in vitro cell culture has been initiated; (Number: NTF16001), from April 2016 to October 2021, 500000.

Research Findings:

1. Yang, P., Chen, Y., Huang, Z., Xia, H., Cheng, L., Wu, H., Zhang, Y. & Wang, F*. Single-cell RNA sequencing analysis of shrimp immune cells identifies macrophage-like phagocytes. eLife. 11:e80127, doi:10.7554/eLife.80127 (2022).

2. Lu, Y., Liu, Q., Huang, Z., Chen, X., Yang, C., Zhang, Y., Zhao, Y*. & Wang, F*. ATP synthase subunit e is a shrimp growth-associated breeding marker. Genomics. 114(4):110410, doi:10.1016/j.ygeno.2022.110410 (2022).

3. Luo, K., Chen, Y. & Wang, F*. Shrimp Plasma MANF Works as an Invertebrate Anti-Inflammatory Factor via a Conserved Receptor Tyrosine Phosphatase. J Immunol. 208(5):1214-1223, doi:10.4049/jimmunol.2100595 (2022).

4. Huang, Z., Yang, P. & Wang, F*. Shrimp Plasma CREG Is a Hemocyte Activation Factor. Front Immunol. 12:707770, doi:10.3389/fimmu.2021.707770 (2021).

5. Tao, M., Liang, Y., Zhang, Y. & Wang, F*. A novel WSSV responsive plasma protein from Litopenaeus vannamei contributes to hemocytes anti-apoptosis. Mol Immunol. 120:113-121, doi:10.1016/j.molimm.2020.02.007 (2020).

6. Tao, M., Zhou, H., Luo, K., Lu, J., Zhang, Y. & Wang, F*. Quantitative serum proteomics analyses reveal shrimp responses against WSSV infection. Dev Comp Immunol. 93:89-92, doi:10.1016/j.dci.2019.01.003 (2019).

7. Chen, Y., Luo, K., Zhang, B., Lu, Z., Wang, F*. Shrimp MANF maintains hemocyte viability via interaction with a tyrosine kinase Abl. Dev Comp Immunol. 143:104675, doi:10.1016/j.dci.2023.104675 (2023).

8. Wang, F., Zhu, Y. & Hew, C. L*. Quantitative study of proteomic alterations in a Zebrafish (danio rerio) cell line infected with the Singapore Grouper Iridovirus (SGIV). Virus Res. 199:62-67, doi:10.1016/j.virusres.2015.01.025 (2015).

9. Wang, F., Bi, X., Chen, L. M. & Hew, C. L*. ORF018R, a highly abundant virion protein from Singapore grouper iridovirus, is involved in serine/threonine phosphorylation and virion assembly. J Gen Virol. 89(Pt 5):1169-1178, doi:10.1099/vir.0.83639-0 (2008).

10. Wang, F., Wang, X., Liu, Y., Tian, W. X. & Zhou, H. M*. Inhibitive effect of zinc ion on fatty acid synthase from chicken liver. Int J Biochem Cell Biol. 35(3):391-400, doi:10.1016/s1357-2725(02)00267-4 (2003).