I. BRIEF INTRODUCTION

Prof. Chiju WEI

Ph.D. (University of Science and Technology of China)

E-mail: chijuwei@stu.edu.cn

Educational Background:

Ph.D., In 1988, University of Science and Technology of China

M.S. and B.S. in 1998, University of Connecticut, USA

Work Experience:

From 1998 to 2001, Conducted research on mouse β cells at the Fox Chase Cancer Research Center in Philadelphia, USA.

From 2001 to 2005, Researched the development of human pancreatic β cells at the National Institutes of Health, USA.

From 2005 to present, Professor at the Multidisciplinary Research Center of Shantou University

Courses Taught:

Basic Molecular Biology Frontier Advances in Life Sciences Main Research Interests: Development of pancreatic Beta cells, prevention and treatment of diabetes, cell senescence, molecular therapy, synthetic biology

II.REASEARCH

Projects Undertaken:

[1] General Project of the National Natural Science Foundation of China: Construction of Novel Non-viral Integrating Vectors and Their Application in the Prevention and Treatment of Type 1 Diabetes; (Project Number: 81172894)

[2] General Project of the National Natural Science Foundation of China: Application of Lentiviral Vectors in New Strategies for Studying the Mechanism of Adult Islet Generation; (Project Number: 30971665)

Research Findings:

[1] Shui-li Zhang, De-jin Zheng, Wen-zhu Fan, Dai-xu Wei, Si-wu Peng, Mi-mi Tang, Guo-Qiang Chen, Chi-ju Wei；Transient embolization with microspheres of polyhydroxyalkanoate renders efficient adenoviral transduction of pancreatic capillary in vivo.；Journal of Gene Medicine 14: 530–539；

[2] Hong-ming Li, Mei Zhang, Di-zheng Li, Sheng-tao Xu, Lin-yun Zhu, Si-wu Peng, Guo-qiang Chen, Pamela M. Martin, Vadivel Ganapathy, Chi-ju Wei；Nicotinic Acid Inhibits Glucose Stimulated Insulin Secretion Via The G-Protein Coupled Receptor PUMA-G on Murine Islet beta-Cells；Pancreas. 40:615-621；

[3] Mi-mi Tang, Qin-e Zhu, Wen-zhu Fan, Shui-li Zhang, Di-zheng Li, Li-zhong Liu, Miao Chen, Mei Zhang, Jing Zhou, Chi-ju Wei；Intra-Arterial Targeted Islet-Specific Expression of Sirt1 Protects Beta Cells from Streptozotocin Induced Apoptosis in Mice.；Molecular Therapy 19:60-66；

[4] Si-wu Peng, Lin-yun Zhu, Miao Chen, Mei Zhang, Di-zheng Li, Yu-cai Fu, Shen-ren Chen, Chi-ju Wei；Heterogeneity in mitotic activity and telomere length implies an important role of young islets in the maintenance of islet mass in the adult pancreas；Endocrinology 150 (7): 3058-3066；

[5] Xiao-Di Yang, Hong-Ming Li, Miao Chen, Xiang-Hui Zou, Lin-Yun Zhu, Guo-Qiang Chen, Chiju Wei；Enhanced Insulin Production from Murine Islet Beta Cells Incubated on Poly (3-Hydroxybutyrate-co-3-Hydroxyhexanoate)；Journal of Biomedical Materials Research Part A 92A (2):548-555；

[6] Chiju Wei, Richard Zeff, and Irving Goldscheider. 2000；Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R, TdT and C m expression；J. Immunology 164:161；

[7] Chiju Wei, Laijun Lai, and Irving Goldscheider. 2002；PPBSF is essential for the up-regulation of IL-7R a on pro-B cells from IL-7 KO mice；Journal of Interferon and Cytokine Research 22(7):823；

[8] Richard R. Hardy, Chiju Wei, and Kyoko Hayakawa. 2004；Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells；Immunol. Rev. 197:60-74；

[9] Marvin C. Gershengorn, Anandwardhan A. Hardikar, Chiju Wei, Elizabeth Geras-Raaka, Bernice Marcus-Samuels, Bruce M. Raaka. 2004；Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells；Sciences 306(5705):2261-4；

[10] Chiju Wei, Elizabeth Geras-Raaka, Bernice Samuels, Yoram Oron and Marvin C. Gershengorn. 2005；Trypsin and Thrombin Accelerate Aggregation of Human Endocrine Pancreas Precursor Cells；Accepted to Journal of Cellular Physiology；