Report Title:Biosynthesis of Loline Alkaloids
Abstract:The fungal secondary metabolites, the loline alkaloids, feature a 1-aminopyrrolizidine ring with an unusual strained ether bridge connecting C(2) and C(7). I will discuss what we have learned about the biosynthetic pathway leading to these compounds and the enzymes that catalyze the biosynthetic steps.
Report time:2015-6-5(Fri.)3:30 - 5:00 pm
Report place:ACC 5# meeting room
Reporter:Prof. Robert B. Grossman,Department of Chemistry,University of Kentucky
Reporter summary:
Education A.B. in Chemistry, Certificate of Proficiency in History of Science, Princeton University, Princeton, NJ, 1987
Ph.D., Massachusetts Institute of Technology, Cambridge, MA, 1992
Professional Experience
Summer Undergraduate Research Fellow, Allied-Signal Corp., Morristown, NJ, 1986
Graduate Teaching Assistant, Massachusetts Institute of Technology, 1987
Graduate Research Assistant, Massachusetts Institute of Technology, 1988-92
Postdoctoral Fellow, Massachusetts Institute of Technology, June-July 1992
Postdoctoral Fellow, Cambridge University, Cambridge, England, 1992-93
Research Associate, Cambridge University, Cambridge, England, 1993-94
Assistant Professor, University of Kentucky, 1994-2000
Associate Professor, University of Kentucky, 2000-2004
Professor, University of Kentucky, 2004-present
Director of Graduate Studies, 2006-2009
Current Research Interests
Organic Synthetic Methodology
Asymmetric Synthesis
Natural Products Synthesis
Chemical Ecology
Welcome your attendance!