赵贤亮
博士，副教授，硕士生导师
个人简介：
赵贤亮，男，博士，硕士生导师，汕头大学理学院生物系副教授。2010年获汕头大学理学硕士学位，2014年获中山大学理学博士学位，2015年入职河南师范大学水产学院，2021年香港理工大学基础医学博士后出站，2024年入职汕头大学理学院。
主要研究方向为对虾免疫与病害防控、细菌耐药性防控。主持国家自然科学基金青年、面上项目各1项，广东省自然科学基金面上项目等科研项目13项。以第一作者或通讯作者在Science Translational Medicine, The Journal of Immunology等期刊发表论文28篇，参与发表论文50余篇，获授权国家发明专利6项。主讲本科生《生物化学-下》、《海洋动物免疫学》、《遗传学实验》，研究生《生命科学前言进展》、《海洋科学前言进展》、《水生动物病害诊断与防控》等课程。
教育背景：
2010/09-2014/12：中山大学，生命科学学院，生物化学与分子生物学专业
2007/09-2010/07：汕头大学，理学院，生物化学与分子生物学专业
工作经历：
2024/09 - 至今：汕头大学理学院，副教授
2018/02 - 2021/08：香港理工大学基础医学，博士后
2015/07 - 2024/07：河南师范大学水产学院，副教授
主要承担项目：
1. 国家自然科学基金面上项目、项目编号：32674002、精氨酸增强血蓝蛋白携氧能力的机制及其在对虾抗低氧胁迫中的功能、2027.01-2030.12、50万元、在研、主持
2. 广东省自然科学基金面上项目、项目编号：2025A1515011419、外膜蛋白LamB介导天冬氨酸逆转嗜水气单胞菌耐药性的机制研究、2025.01-2027.12、10万元、在研、主持
3. 中山大学横向课题、项目编号：20240216-H、抗菌新药体药效学研究之（第2份）：抗菌新药最适比例的体内效果评价、2025.01-2027.12、10万元、在研、主持
4. 国家自然科学青年科学基金、项目编号：31502204、对虾血蓝蛋白磷酸化修饰多态性与免疫学意义的研究、2016.01-2018.12、24万元、结题、主持
5. 62批中国博士后科学基金面上资助，项目编号：2017M622351、天冬氨酸基于TLR4/NF-κB途径调控鲤肝炎症反应的机制、2018.01-2019.12、5万元、结题、主持
6. 2017年“香江学者计划”项目、项目编号：XJ2017065、Reversing cancer drug resistance using small molecules、2018.02-2020.02、结题、170万港币（经费访问学校使用）、主持
主要研究成果 (第一/通讯)：
(1) Zhao XL#, Chen ZG#, Yang TC#, Jiang M#, Wang J, Cheng ZX, Yang MJ, Zhu JX, Zhang TT*, Li H*, Peng B*, Peng XX*. Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria. Science Translational Medicine (1区Top，IF: 19.319), 2021, 13(625): eabj0716.
(2) Cui XY, Zhao CF, Jin ZH, Liu YC, Li L, Zhao XL*, Kong XH*. β-globin mediates antimicrobial defense and inflammatory regulation in common carp (Cyprinus carpio). Fish Shellfish Immunol. 2026, 177: 111571. doi: 10.1016/j.fsi.2026.111571.
(3) Fu MS, Wu TC, Feng Q, Aweya JJ, Liao MR, Zheng ZH, Zhao XL*, Zhang YL*. S293 phosphorylation of hemocyanin boosts shrimp antimicrobial immunity via p38 MAPK signaling. Water Biology and Security, 2026, 100684. doi: 10.1016/j.watbs.2026.100684.
(4) Zhou LP, Ma ZT, Chen XL, Liu QY, Huang YL, Yang CL, Zeng DG, Zheng ZH, Zhang B, Zhang YL, Zhao YZ*, Zhao XL*. Carbonic Anhydrase 2 and Na+/K+-ATPase Mediate Family-Dependent Nitrite Tolerance via Modulating Branchial Ion Transport and Acid-Base Balance in Penaeus vannamei. Animals (Basel). 2026, 16(11): 1638. doi: 10.3390/ani16111638.
(5) Shi YY, Kong YH, Bao SY, Zhou YQ, Cheng JW, Zheng ZH, Zhao YZ, Zhao XL*, Zhang YL*. Hemocyanin regulates phosphatidylcholine metabolism to enhance ROS-mediated immunity in Pacific white shrimp (Penaeus vannamei). J Immunol. 2026, 251(3): vkag018.
(6) Qin YM, Chen YP, Zheng ZH, Chen XL, Liu QY, Zhao YZ*, Zhao XL*, Zhang YL*. Gut-derived Weissella paramesenteroides increase resistance to Acute Hepatopancreatic Necrosis Disease (AHPND) in Penaeus vannamei. Fish Shellfish Immunol. 2026, 169: 111025. doi: 10.1016/j.fsi.2025.111025.
(7) Fu MS#, Liao MR#, Qin YM, He LX, Zheng ZH, Zhao YZ, Liu QY, Zhang YL, Zhao XL*. Hemocyanin-derived antimicrobial peptide PvL1 defense against AHPND infection by regulating the hepatopancreatic microbiota of Penaeus vannamei. Fish Shellfish Immunol. 2025, 161: 110267.
(8) Zhou LP, Ma ZT, Liu QY, Li QY, Peng M, Yang CL, Zhang B, Chen TC, Huang YL, Zheng ZH, Huang AG, Chen XL, Zhang YL, Zhao XL*, Zhao YZ*. Shrimp shapes a nitrite tolerance trait via regulating autophagy and apoptosis. Int J Mol Sci. 2025, 26(4): 1641.
(9) Zhao XL, Liu X, Yang YP, Lu YF, Li L, Kong XH*. Myo-inositol enhances the resistance and alleviates inflammation of Cyprinus carpio to Aeromonas hydrophila infection. Aquaculture (1区，IF: 3.9), 2024, 578, 740056.
(10) Zhao XL, Liu Y, Yan F, Lin ZY, Zhao YZ, Chen XL, Zhang YL*. OmpU and OmpC are the key OMPs for Litopenaeus vannamei hemocyanin recognizes Vibrio parahaemolyticus. Fish Shellfish Immunol (2区，IF: 4.1). 2024, 146: 109409.
(11) Zhao XL#, Yang D#, Zhong MQ, Lin ZY, Yao DF, Zhang YL*. LamB as a potential negative regulator to the immune response of shrimp Litopenaeus vannamei upon Vibrio parahaemolyticus infection. Aquaculture (1区，IF: 4.5), 2023, 572: 739544.
(12) Zhao XL, Cui XY, Yang YP, Zhu L, Li L, Kong XH*. Synergistic effect of quercetin on antibacterial activity of florfenicol against Aeromonas hydrophila in vitro and in vivo. Antibiotics (Basel) (2区，IF: 5.222), 2022, 11(7): 929.
(13) Zhao XL#, Qiao J#, Zhang P, Zhang ZH, Aweya JJ, Chen XH, Zhao YZ, Zhang YL*. Protein diversity and immune specificity of hemocyanin from shrimp Litopenaeus vannamei. Frontiers in Immunology (2区，IF: 8.786), 2021, 12: 772091.
(14) Zhao XL, Yang YP, Wang L, Chen H, Zhu L, Li L, Kong XH*. Aspartate induces metabolic changes and improves the host's ability to fight against Aeromonas hydrophila infection in Cyprinus carpio. Aquaculture Research (3区，IF: 2.184), 2022, 53(3), 1050-1061.
(15) Zhao XL, Wu G, Chen H, Li L, Kong XH*. Analysis of virulence and immunogenic factors in Aeromonas hydrophila: Towards the development of live vaccines. Journal of Fish Diseases (2区，IF: 2.318), 2020, 43(7), 747-755.
(16) Zhao XL, Chen H, Jin ZH, Li L, Zhang J, Kong XH*. GC-MS-based metabolomics analysis reveals L-aspartate enhances the antibiotic sensitivity of neomycin sulfate-resistant Aeromonas hydrophila. Journal of Fish Diseases (2区，IF: 2.004), 2018, 41(12), 1831-1841.
(17) Zhao XL, Jin ZH, Di GL, Li L, Kong XH*. Molecular characteristics, pathogenicity and medication regimen of Aeromonas hydrophila isolated from common carp (Cyprinus carpio L.). Journal of Veterinary Medical Science (4区，IF: 1.049). 2019, 81(12): 1769-1775.
(18) Zhao XL, Chen H, Zhong KK, Li L, Kong XH*. Myo-inositol as an adjuvant to florfenicol against Aeromonas hydrophila infection in common carp. FEMS Microbiology Letters (4区，IF: 1.994), 2018, 365(20), fny212.
(19) Zhao XL, Guo LL, Lu X, Wang F, Zhong MQ, Chen JH, Zhang YL*. Evidences of abundant hemocyanin variants in shrimp Litopenaeus vannamei. Molecular Immunology (3区，IF: 3.375), 2016, 77: 103-112.
(20) Zhao XL, Han Y, Ren ST, Ma YM, Li H, Peng XX*. L-proline increases survival of tilapias infected by Streptococcus agalactiae in higher water temperature. Fish Shellfish Immunology (2区，IF: 3.025), 2015, 44: 33-42.
(21) Zhao XL, Wu CW, Peng XX*, and Li H. Interferon-α2b against microbes through promoting biosynthesis of unsaturated fatty acids. Journal of Proteome Research (2区，IF: 5.002), 2014, 13 (9): 4155-4163.
(22) Guo LL#, Zhao XL#, Zhang YL*, Wang ZH, Zhong MQ, Li SK, Lun JS. Evidences of SNPs in the variable region of hemocyanin Ig-like domain in shrimp Litopenaeus vannamei. Fish Shellfish Immunology (2区，IF: 3.025), 2013, 35 (5): 1532-1538.
(23) Zhao XL, Guo LL, Zhang YL*, Liu Y, Zhang XY, Lun JS, Chen JH, Li YY. SNPs of hemocyanin C-terminal fragment in shrimp Litopenaeus vannamei. FEBS Letters (3区，IF: 3.519), 2012, 586 (4): 403-410.
(24) Zheng LY#, Zhao XL#, Zhang P, Chen CD, Liu S, Huang R, Zhong MQ, Wei CJ, Zhang YL*. Hemocyanin from shrimp Litopenaeus vannamei has antiproliferative effect against HeLa cell In vitro. PLoS One (3区，IF: 3.057), 2016, 11(3):e0151801.
(25) Wu CW#, Zhao XL#, Wu XJ, Wen C, Li H, Chen XH, Peng XX*. Exogenous glycine and serine promote growth and antifungal activity of Penicillium citrinum W1 from the south-west Indian Ocean. FEMS Microbiology Letters (4区，IF: 1.858), 2015, 362(8): fnv040.
(26) 赵贤亮, 靳朝晖, 黄莎妮, 陈鹤, 李莉, 孔祥会*. L-半胱氨酸提高嗜水气单胞菌对氟苯尼考敏感性的研究[J]. 水产学报, 2019, 43(03):125-132.
(27) 赵贤亮, 陈鹤, 孔祥会*. 代谢组学技术在水产动物疾病研究中的应用[J]. 中国生物化学与分子生物学报, 2018, 34 (9), 942-948.
(28) 赵贤亮, 陈鹤, 杨潇, 巴新霞, 李莉, 孔祥会*. 黄河鲤嗜水气单胞菌的分离、毒力及用药分析[J]. 水产科学, 2017, 36(5):642-646.
授权专利：
(1) 赵贤亮，孔祥会，李莉，张杰，陈鹤，一种用于防治鱼类肝脏炎症的药物组合物，2021.06.29，发明专利，授权专利号：ZL201811459002.1
(2) 孔祥会，赵贤亮，张杰，李莉，陈鹤，梁旭晨，王莉平，一种嗜水气单胞菌活菌疫苗菌株的筛选方法，2021.05.04，发明专利，授权专利号：ZL201710094067.X
(3) 赵贤亮，孔祥会，李莉，陈鹤，钟科珂，杨潇，巴新霞，肌醇作为氟苯尼考增效剂的应用，2019.12.03，发明专利，授权专利号：ZL201710047078.2
(4) 彭宣宪，李惠，赵贤亮，Small molecular substance for improving sensitivity of bacteria to antibiotics, 2015.10.22, 美国，授权专利号：US20150297547A1
(5) 彭宣宪，李惠，赵贤亮，一种提高细菌对抗生素敏感性的小分子物质，2013.03.20，发明专利，授权专利号：ZL201210511911.1
(6) 彭宣宪，李惠，赵贤亮，一种提高抗生素清除病原菌的小分子代谢物，2015.05.13，发明专利，授权专利号：ZL201410846650.8
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通讯地址
地址：高水平楼A座416
E-mail: xlzhao1@stu.edu.cn
