李锐鑫 博士、讲师

2023年博士毕业于华东师范大学，主要从事水生动物营养与生理代谢研究，重点关注胆固醇在鱼类营养代谢中的功能与调控作用。近年来，以第一作者或通讯作者在《Maine Life Science & Technology》、《Aquaculture》、《American Journal of Physiology-regulatory Integrative and Comparative Physiology》等国际期刊发表SCI论文13篇。

办公地点：I座204；电话：13590043790；E-mail: rxli@stu.edu.cn；rui_xin_li@126.com

工作经历：

2023.06至今    汕头大学   讲师

主要研究兴趣：

胆固醇在鱼类营养代谢中的功能与调控作用研究;

鱼类机体胆固醇蓄积的分子机理研究；

减少鱼类胆固醇蓄积的有效方式及其分子调控机制研究；

承担项目：

汕头大学科研启动经费项目（NTF23031）：高糖摄入诱导黄斑蓝子鱼肝脏胆固醇蓄积的分子机制，2023.11-2026.11，50万元，主持。

广东省基础与应用基础研究基金项目（2024A1515110025）：高脂饲料诱导Srebp2乙酰化修饰导致罗非鱼胆固醇蓄积的作用机制研究，2025.01-2027.12，10万元，主持。

指导本科生成果：

获奖情况：

第十八届“挑战杯”全国大学生课外学术科技作品竞赛（获得广东省赛区二等奖: 黄启茗、张荟雯、谢嘉颖、肖毅、欧阳敏、刘景文、孔泽轩）；

第九届全国大学生生命科学竞赛（获得广东省赛区三等奖: 谢嘉颖、肖毅、张荟雯、黄启茗）；

广东省生物化学实验技能大赛（获得三等奖：欧阳敏、宋嘉祺、陈美臻）。

科研情况：

以第一作者身份发表SCI论文2篇（中科院一区TOP）：

1. Huang, Q.M. (黄启茗), Zhang, H.W. (张荟雯), Su, X.B., Xiao, Y. (肖毅), Xie, J.Y. (谢嘉颖), Tocher, D.R., Lin F., Chen C.Y., Wang, S.Q.*, Li. R.X. (李锐鑫)*. Docosahexaenoic acid alleviated liver lipid deposition and health damage induced by cholesterol accumulation in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂). Aquaculture, 2025, 596, 741877.

2. Xiao, Y. (肖毅), Su, X.B., Xie, J.Y. (谢嘉颖), Zhang. H.W. (张荟雯), Huang, Q.M. (黄启茗), Tocher, D.R., Lin, F., Chen, C.Y., Wang, S.Q.*, Li, R.X. (李锐鑫)*. Dietary trehalose reduced liver glycogen accumulation and promoted protein deposition in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂) fed a high-carbohydrate diet. Aquaculture 2025;605:742544.

（欢迎有想法、能安心、肯吃苦、想接受科研思维训练与继续深造的有志青年们加入团队！）

研究成果（#为共同第一作者；*为通讯作者）：

Huang, Q.M., Zhang, H.W., Su, X.B., Xiao, Y., Xie, J.Y., Tocher, D.R., Lin F., Chen C.Y., Wang, S.Q.*, Li. R.X.* Docosahexaenoic acid alleviated liver lipid deposition and health damage induced by cholesterol accumulation in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂). Aquaculture, 2025, 596, 741877.

Xiao, Y., Su, X.B., Xie, J.Y., Zhang. H.W., Huang, Q.M., Tocher, D.R., Lin, F., Chen, C.Y., Wang, S.Q.*, Li, R.X.* Dietary trehalose reduced liver glycogen accumulation and promoted protein deposition in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂) fed a high-carbohydrate diet. Aquaculture 2025;605:742544.

Liu, Z.X., Xiao, Y., Xie, J.Y., Zhang, H.W., Huang, Q.M., Monroig, Ó., Tocher, D.R., Liu, X.J., Lin, F., Chen, C.Y., Wang, S.Q., Li, R.X.* Cholesterol Accumulation Caused Oxidative Stress Associated With Impaired Antioxidant Capability and Mitochondrial Function in the Liver of Nile Tilapia. Aquaculture Nutrition 2025; 2025:7643962.

Li, R.X., Chen, L.Y., Limbu, S.M., Yao, B., Qian, Y.C., Zhou, W.H., Chen, L.Q., Luo, Y.,Qiao, F., Zhang, M.L., Du, Z.Y.*, 2023. High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia. Maine Life Science & Technology 5, 56–74.

Li, R.X., Chen, L.Y., Yao, B., Rahimnejad, S., Ren, J., Luo, Y., Qiao, F., Zhang, M.L., Du, Z.Y.*, 2022. Trehalose alleviated hepatic cholesterol accumulation via inhibiting transformation from glucose-derived acyl-CoA to cholesterol synthesis in Nile tilapia. Aquaculture 560, 738600.

Li, R.X., Chen, L.Y., Limbu, S.M., Yao, B., Qian, Y.F., Zhou, W.H., Chen, L.Q., Qiao, F., Zhang, M.L., Du, Z.Y., Luo, Y.*, 2023. Atorvastatin remodels lipid distribution between liver and adipose tissues through blocking lipoprotein efflux in fish. American Journal of Physiology-regulatory Integrative and Comparative Physiology 324(3):R281-R292.

Li, R.X., Qian, Y.F., Zhou, W.H., Wang, J.X., Zhang, Y.Y., Luo, Y., Qiao, F., Chen, L.Q., Zhang, M.L., Du. Z.Y.*, 2022. The adaptive characteristics of cholesterol and bile acid metabolism in Nile tilapia fed a high-fat diet. Aquaculture Nutrition 2022, 8016616.

Li, R.X., Zhou, W.H., Ren, J., Wang, J., Qiao, F., Zhang, M.L., Du, Z.Y.*, 2022. Dietary sodium lactate promotes protein and lipid deposition through increasing energy supply from glycolysis in Nile tilapia (Oreochromis niloticus). Aquaculture 550, 737858.

Li, R.X., Chen Q., Liu, H.Y., Tan, B.P.*, Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., 2018. Molecular characterization and expression analysis of glucose transporter 4 from Trachinotus ovatus, Rachycentron canadums and Oreochromis niloticus in response to different dietary carbohydrate-to-lipid ratios. Aquaculture 501, 430-440.

Li, R.X., Liu, H.Y., Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., Tan, B.P.*, 2018. Molecular characterization and expression analysis of glucose transporter 1 and hepatic glycolytic enzymes activities from herbivorous fish Ctenopharyngodon idellus in respond to a glucose load after the adaptation to dietary carbohydrate levels. Aquaculture 492, 290-299.

Li, R.X., Liu, H.Y., Li, S.Y., Tan, B.P.*, Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., Chen, L. Q., 2019. Nutritional regulation of pyruvate kinase and phosphoenolpyruvate carboxykinase at the enzymatic and molecular levels in cobia Rachycentron canadum. Fish Physiology Biochemistry 45, 1015–1028 .

Li, R.X., Liu, H.Y., Li, S.Y., Tan, B.P.*, Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., Chen, L. Q., 2018. Nutritional regulation of gene expression and enzyme activity of phosphoenolpyruvate carboxykinase in the hepatic gluconeogenesis pathway in golden pompano (Trachinotus ovatus). Aquaculture Research 50, 634–643.

Li, R.X., Liu, H.Y., Chen, Q., Tan, B.P.*, Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., Chen, L.Q., 2018. Glucose tolerance of grass carp Ctenopharyngodon idellus after a long-term adaptation to carbohydrate‐to‐lipid ratio diets. Aquaculture Research 49, 3881–3888.