李锐鑫 （博士）、硕士生导师、讲师

2023年博士毕业于华东师范大学，主要从事水生动物营养与生理代谢研究，重点关注胆固醇在鱼类营养代谢中的功能与调控作用。近年来，以第一作者或通讯作者在《Maine Life Science and Technology》、《Water Biology and Security》《Aquaculture》、《American Journal of Physiology-regulatory Integrative and Comparative Physiology》等国际期刊发表SCI论文13篇。

办公地点：I座204；电话：13590043790；E-mail: rxli@stu.edu.cn；rui_xin_li@126.com

工作经历：

2023.06 至今 汕头大学 讲师

主要研究兴趣：

胆固醇在鱼类营养代谢中的功能与调控作用研究;

鱼类胆固醇蓄积的发生机理研究；

减少鱼类胆固醇蓄积的有效方式及其分子调控机制研究；

承担项目：

Ø 汕头大学科研启动经费项目（NTF23031）：高糖摄入诱导黄斑蓝子鱼肝脏胆固醇蓄积的分子机制，2023.11-2026.11，50万元，主持。

Ø 广东省基础与应用基础研究基金项目（2024A1515110025）：高脂饲料诱导Srebp2乙酰化修饰导致罗非鱼胆固醇蓄积的作用机制研究，2025.01-2027.12，10万元，主持。

Ø 广东省基础与应用基础研究基金项目（2026A1515010634）：胆固醇蓄积对罗非鱼肝脏健康的损伤作用机制研究，2026.01-2028.12，10万元，主持。

指导本科生成果：

本科生获奖情况：

Ø 第十八届“挑战杯”全国大学生课外学术科技作品竞赛（获得广东省赛区二等奖: 黄启茗、张荟雯、谢嘉颖、肖毅、欧阳敏、刘景文、孔泽轩）；

Ø 第九届全国大学生生命科学竞赛（获得广东省赛区三等奖: 谢嘉颖、肖毅、张荟雯、黄启茗）；

Ø 2024年广东省生物化学实验技能大赛（获得三等奖：欧阳敏、宋嘉祺、陈美臻）；

Ø 2025年广东省生物化学实验技能大赛（获得二等奖：刘景文、孔泽轩、刘探）。

本科生科研成果情况：

以第一/共同第一作者身份发表SCI论文3篇（#为共同第一作者；*为通讯作者）：

1. Huang, Q.M. (黄启茗), Zhang, H.W. (张荟雯), Su, X.B., Xiao, Y. (肖毅), Xie, J.Y. (谢嘉颖), Tocher, D.R., Lin F., Chen C.Y., Wang, S.Q.*, Li. R.X. (李锐鑫)*. Docosahexaenoic acid alleviated liver lipid deposition and health damage induced by cholesterol accumulation in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂). Aquaculture, 2025, 596, 741877.（中科院一区TOP期刊）

2. Xiao, Y. (肖毅), Su, X.B., Xie, J.Y. (谢嘉颖), Zhang. H.W. (张荟雯), Huang, Q.M. (黄启茗), Tocher, D.R., Lin, F., Chen, C.Y., Wang, S.Q.*, Li, R.X. (李锐鑫)*. Dietary trehalose reduced liver glycogen accumulation and promoted protein deposition in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂) fed a high-carbohydrate diet. Aquaculture 2025; 605:742544.（中科院一区TOP期刊）

3. Li, R.X. (李锐鑫) ^#, Liu, J.W (刘景文) ^#, Liang, J.Y., Liang, L. (梁朗), Kong, Z.X. (孔泽轩), Liu, T. (刘探), Liu, X.J., Lin, F., Chen, C.Y., Du, Z.Y.*, Wang, S.Q.* Insufficient or excessive niacin intake induced glucose and lipid metabolic disorders and impaired liver health in Nile Tilapia. Aquaculture Nutrition 2026; 3445390.（中科院二区期刊）

（欢迎有想法、能安心、肯吃苦、想接受科研思维训练与继续深造的有志青年们加入团队！）

研究成果（#为共同第一作者；*为通讯作者）：

l Li, R.X., Luo, Y., Han, S.L., Zhou, W.H., Chen, L.Q., Qiao, F., Chu, W.Y., Zhang, M.L., Du, Z.Y., 2026. Lysosomal acid lipase is essential in cholesterol-mediated mTORC1 signaling activation by maintaining a balance between cholesterol ester and free cholesterol in zebrafish. Water Biology and Security 2026: 100551.

l Huang, Q.M., Zhang, H.W., Su, X.B., Xiao, Y., Xie, J.Y., Tocher, D.R., Lin F., Chen C.Y., Wang, S.Q.*, Li. R.X.*, 2025. Docosahexaenoic acid alleviated liver lipid deposition and health damage induced by cholesterol accumulation in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂). Aquaculture 596, 741877.

l Xiao, Y., Su, X.B., Xie, J.Y., Zhang. H.W., Huang, Q.M., Tocher, D.R., Lin, F., Chen, C.Y., Wang, S.Q.*, Li, R.X.*, 2025. Dietary trehalose reduced liver glycogen accumulation and promoted protein deposition in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂) fed a high-carbohydrate diet. Aquaculture 605:742544.

l Liu, Z.X., Xiao, Y., Xie, J.Y., Zhang, H.W., Huang, Q.M., Monroig, Ó., Tocher, D.R., Liu, X.J., Lin, F., Chen, C.Y., Wang, S.Q., Li, R.X.*, 2025. Cholesterol Accumulation Caused Oxidative Stress Associated With Impaired Antioxidant Capability and Mitochondrial Function in the Liver of Nile Tilapia. Aquaculture Nutrition; 2025:7643962.

l Li, R.X., Chen, L.Y., Limbu, S.M., Yao, B., Qian, Y.C., Zhou, W.H., Chen, L.Q., Luo, Y., Qiao, F., Zhang, M.L., Du, Z.Y.*, 2023. High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia. Maine Life Science and Technology 5, 56–74.

l Li, R.X., Chen, L.Y., Yao, B., Rahimnejad, S., Ren, J., Luo, Y., Qiao, F., Zhang, M.L., Du, Z.Y.*, 2022. Trehalose alleviated hepatic cholesterol accumulation via inhibiting transformation from glucose-derived acyl-CoA to cholesterol synthesis in Nile tilapia. Aquaculture 560, 738600.

l Li, R.X., Chen, L.Y., Limbu, S.M., Yao, B., Qian, Y.F., Zhou, W.H., Chen, L.Q., Qiao, F., Zhang, M.L., Du, Z.Y., Luo, Y.*, 2023. Atorvastatin remodels lipid distribution between liver and adipose tissues through blocking lipoprotein efflux in fish. American Journal of Physiology-regulatory Integrative and Comparative Physiology 324(3):R281-R292.

l Li, R.X., Qian, Y.F., Zhou, W.H., Wang, J.X., Zhang, Y.Y., Luo, Y., Qiao, F., Chen, L.Q., Zhang, M.L., Du. Z.Y.*, 2022. The adaptive characteristics of cholesterol and bile acid metabolism in Nile tilapia fed a high-fat diet. Aquaculture Nutrition 2022, 8016616.

l Li, R.X., Zhou, W.H., Ren, J., Wang, J., Qiao, F., Zhang, M.L., Du, Z.Y.*, 2022. Dietary sodium lactate promotes protein and lipid deposition through increasing energy supply from glycolysis in Nile tilapia (Oreochromis niloticus). Aquaculture 550, 737858.

l Li, R.X., Chen Q., Liu, H.Y., Tan, B.P.*, Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., 2018. Molecular characterization and expression analysis of glucose transporter 4 from Trachinotus ovatus, Rachycentron canadums and Oreochromis niloticus in response to different dietary carbohydrate-to-lipid ratios. Aquaculture 501, 430-440.

l Li, R.X., Liu, H.Y., Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., Tan, B.P.*, 2018. Molecular characterization and expression analysis of glucose transporter 1 and hepatic glycolytic enzymes activities from herbivorous fish Ctenopharyngodon idellus in respond to a glucose load after the adaptation to dietary carbohydrate levels. Aquaculture 492, 290-299.

l Li, R.X., Liu, H.Y., Li, S.Y., Tan, B.P.*, Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., Chen, L. Q., 2019. Nutritional regulation of pyruvate kinase and phosphoenolpyruvate carboxykinase at the enzymatic and molecular levels in cobia Rachycentron canadum. Fish Physiology Biochemistry 45, 1015–1028 .

l Li, R.X., Liu, H.Y., Li, S.Y., Tan, B.P.*, Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., Chen, L. Q., 2018. Nutritional regulation of gene expression and enzyme activity of phosphoenolpyruvate carboxykinase in the hepatic gluconeogenesis pathway in golden pompano (Trachinotus ovatus). Aquaculture Research 50, 634–643.

l Li, R.X., Liu, H.Y., Chen, Q., Tan, B.P.*, Dong, X.H., Chi, S.Y., Yang, Q.H., Zhang, S., Chen, L.Q., 2018. Glucose tolerance of grass carp Ctenopharyngodon idellus after a long-term adaptation to carbohydrate‐to‐lipid ratio diets. Aquaculture Research 49, 3881–3888.