师资团队
教授
其他骨干教师
行政—教辅
物理系
生物系
海洋科学研究所


个人简介

姚德福,男,生日:19891月。

Email: dfyao@stu.edu.cn

手机:0754-86503273

教育背景:

2011.09 - 2016.07 厦门大学 生命科学学院 博士

2007.09 - 2011.07  江西中医学院 基础医学院 学士

工作经历:

2023.01 –至今 汕头大学 副教授

2019.09 – 2022.12  汕头大学 讲师

2016.09 – 2019.09  汕头大学   博士后

2017.07 – 2018.07  新加坡国立大学   访问学者

研究方向:

以我国对虾养殖主导品种-凡纳滨对虾为研究象,针对对虾养殖中主要病原-白斑综合症病(WSSV)和副溶血弧菌等,综合利用分子生物学、细胞生物学以及分子免疫学等技术,开展病原感染机制和宿主免疫防御机制等两个方面的研究工作。


教学情况:

承担三门本科生课程(免疫学、海洋动物免疫学,细胞生物学实验)以及一门研究生课程(现代分子免疫学及其研究技术研究进展)


人才培养情况:

1、指导本科生参加全国大学生命科学竞赛(科学探究类)获全国一等奖1次和广东省三等奖3次;指导本科生毕业设计获得汕头大学优秀毕业论文2;

2、指导硕士研究生 6人,已毕业 1人。


主持科研项目情况

1、国家自然科学基金面上项目:白斑综合症病毒IE1蛋白调控对虾PI3K-AKT信号通路的分子机制与功能,编号:3217301758万元,在研,主持;

2、国家自然科学基金青年科学基金项目:白斑综合症病毒IE1诱导凡纳滨对虾STAT磷酸化的分子机制及功能研究,编号:3170238724万元,已结题,主持;

3、广东省科技计划项目:白斑综合症病毒 IE1 蛋白抑制对虾酚氧化酶原系统的机制研究,编号:STKJ20211885万元, 已结题,主持;

4、中国博士后科学基金面上项目(一等资助): 基于BioID技术的白斑综合症病毒IE1互作蛋白质组学研究,编号:2018M6309738万元,已结题,主持;

5、汕头大学科研启动经费项目:WSSV细胞受体的鉴定及其介导病毒进入的机制研究,编号:NTF20008100万元,在研,主持。

论文发表情况:(#代表并列第一作者,*代表通讯作者或共同通讯作者)

研究方向一:对虾病原感染机制研究

1. Wu TC#, Sun BB#, Lu KY#, Zhang J, Zhang S, Lin ZY, Zhang YL, Zhu JH*, Yao DF*, The MEF2 homolog of Penaeus vannamei is essential for maintaining the WSSV latent infection, Gene, 2023, 147677. (JCR 2 区,IF5Y=3.3)

2. Wang CQ, Zhang HM, Zhu JH, Liu HP, Yang YQ, Sun BB, Wu TC, Zhang YL, Yao DF*, The transcription factor CEBP homolog of Penaeus vannamei contributes to WSSV replication, Fish Shellfish Immunol, 2023,13:108571.JCR 1区,IF5Y=4.7, Top期刊

3. Chen YX#, Wu GC#, Wang CQ, Zhang HM, Zhu JH, Zhang YL, Lin ZY, Yao DF*, Comparative transcriptome analysis reveals that WSSV IE1 protein plays a crucial role in DNA replication control, Int J Mol Sci, 2022, 23, 8176. (JCR 1区,IF5Y=6.2, Top 期刊)

4. Wang CQ#, Wei MH#, Wu GC, He LX, Zhu JH, Aweya JJ, Chen XL, Zhao YZ, Zhang YL, Yao DF*, Proteomics analysis reveals a critical role for the WSSV immediate-early protein IE1 in modulating the host prophenoloxidase system, Virulence, 2022,13(1):936-948.JCR 2 区,IF5Y= 5.9

5. Wei MH#, Zhang YL#, Aweya JJ, Wang F, Li SK, Lun JS, Zhu CH, Yao DF*, Litopenaeus vannamei Src64B restricts white spot syndrome virus replication by modulating apoptosis, Fish Shellfish Immunol, 2019,93:313-321.JCR 1区,IF5Y=4.7, Top期刊

6. Yao DF#, Ruan LW#*, Xu JX#, Shi H, Xu X, Characterization of a novel non-receptor tyrosine kinase Src from Litopenaeus vannamei and its response to white spot syndrome virus infection, Fish Shellfish Immunol, 2017,68:377-385.JCR 1 区,IF5Y=4.7

7. Yao DF#, Ruan LW#*, Lu HS, Shi H, Xu X, Shrimp STAT was hijacked by white spot syndrome virus immediate-early protein IE1 involved in modulation of viral genes, Fish Shellfish Immunol, 2016,59:268-275.JCR 1区,IF5Y=4.7, Top期刊)

8. Yao DF, Ruan LW, Xu X, Shi H*, Identification of a c-Jun homolog from Litopenaeus vannamei as a downstream substrate of JNK in response to WSSV infection, Dev Comp Immunol, 2015,49(2):282-289.JCR 1区,IF5Y=3.1

9. Wang CQ, Yao DF*, Zhao MM, Lu KY, Lin ZY, Chen XL, Zhao YZ, Zhang YL*, Shrimp lipid droplet protein Perilipin involves in the pathogenesis of AHPND-causing Vibrio parahaemolyticus, Int J Mol Sci, 2022, 23,10520. (JCR 1区,IF5Y=6.2, Top 期刊)

10. Wu GC#, Lin QS#, Lim TK, Zhang YL, Aweya JJ, Zhu JH, Yao DF*; The interactome of Singapore grouper iridovirus protein ICP18 as revealed by proximity-dependent BioID approach, Virus Res, 2021, 291:198218.JCR 2区,IF5Y=4.0

11. Yao DF#, Liu YF#, Chen XL#, Lim TK, Wang L, Aweya JJ, Zhang YL*, Lin QS*, In-depth proteomic profiling of the Singapore grouper iridovirus virion, Arch Virol, 2019,164(7):1889-1895.JCR 3区,IF5Y=2.4


研究方向二:对虾免疫防御机制研究

1. Wang ZY, Zhang YL, Aweya JJ, Lin ZY, Yao DF*, Zheng ZH*, The histidine phosphatase LHPP of Penaeus vannamei is involved in shrimp hemocytes apoptosis, Fish Shellfish Immunol Rep, 2023, 5: 100109.

2. Zhao WL#, Fang YX#, Zheng ZH, Lin ZY, Zhao YZ, Chen XL, Yao DF*, Zhang YL*, The transcription factor CSL homolog in Penaeus vannamei positively regulates the transcription of the hemocyanin small subunit gene, Dev Comp Immunol,145, 2023, 104723. JCR 1区,IF5Y=3.1

3. Zhou H#, Chen XB#, Aweya JJ, Zhao YZ, Yao DF*, Zhang YL*, Interaction of Penaeus vannamei hemocyanin and α2-macroglobulin modulates the phenoloxidase activity, Mol Immunol, 2021, 138: 181-187.JCR 3 区,IF5Y= 4.0

4. Zhou H, Zhao WL, Zheng ZH, Aweya JJ, Zhang YL, Zhu JH, Zhao YZ, Chen XL, Yao DF*, The Notch receptor-ligand Delta is involved in the immune response of Penaeus vannamei, Dev Comp Immunol, 2021, 104147.JCR 1区,IF5Y=3.1

5. Zhao WL, Zheng ZH, Aweya JJ, Wang F, Li SK, Tuan TN, Yao DF*, Zhang YL*, Litopenaeus vannamei Notch interacts with COP9 signalosome complex subunit 1 (CNS1) to negatively regulate the NF-κB pathway, J Proteomics, 2021, 234:104104. JCR 2区,IF5Y=3.5

6. Yao DF#, Wang ZH#, Wei MH, Zhao XL, Aweya JJ, Zhong MQ, Li SK, Zhang YL*, Analysis of Litopenaeus vannamei hemocyanin interacting proteins reveals its role in hemolymph clotting, J Proteomics, 2019,201:57-64.JCR 2区,IF5Y=3.5

7. Yao DF#, Su HM#, Zhu JH#, Zhao XL, Aweya JJ, Wang F, Zhong MQ, Zhang YL*, SNPs in the Toll1 receptor of Litopenaeus vannamei are associated with immune response, Fish Shellfish Immunol, 2018,72:410-417. JCR 1 区,IF5Y=4.7, Top期刊