1. 国家自然科学基金（面上项目），32373108，CTGF通过TGF-β/Smads通路调控鱼鳔胶原蛋白合成的分子机制研究，2024-2027，在研，主持

2. 广东省自然科学基金（面上项目），2022A1515010778，浅色黄姑鱼CTGF关键转录因子鉴定及其在鱼鳔胶原蛋白合成中的作用研究，2022-2024，在研，主持

3. 广东省科技计划项目，STKJ202209036，浅色黄姑鱼性别特异性标记开发及应用，2022-2025，在研，主持

4. 广东省科技计划项目，STKJ2021099，高效环保提高鱼鳔品质的浅色黄姑鱼配合饲料研发及应用，2021-2023，在研，主持

5. 广东省普通高校重点领域专项，2022ZDZX4006，高品质鱼鳔生产的功能性配合饲料开发及应用，2023-2025，在研，主持

6. 国家自然科学基金青年基金，81702764，CRISPR/Cas9光控基因线路靶向干预膀胱癌的研究，2018-2020，结题，主持

7. 中国博士后基金，2015M582463，基于Crispr/Cas9光控基因表达系统干预膀胱癌的研究，2015-2017，结题，主持

• 主要论文：

1. Guo HJ^#, Zhang QH^#, Liu X, Zhang HR, Wang SQ, Wen XB*, Lin F*. Dietary hydroxyproline promotes collagen deposition in swim bladder through regulating biosynthesis of amino acid: In-vitro and in-vivo investigations in Nibea coibor. Aquaculture. 2023, 573: 739614.

2. Lin F^#,* Yuan YY^#, Ye XK, Lv JH, Liu X, Guo HJ, Wen XB. Characterization and role of connective tissue growth factor gene in collagen synthesis in swim bladder of chu’s croaker (Nibea coibor). International Journal of Biological Macromolecules. 2023, 227: 1336-1345.

3. Xiao LF^#, Lv JH^#, Liang YJ, Zhang HR, Zheng J, Lin F*, Wen XB*. Structural, physicochemical properties and function of swim bladder collagen in promoting fibroblasts viability and collagen synthesis. LWT-Food Science and Technology. 2023, 173: 114294.

4. Xiao LF, Liang YJ, Liu Geng, Lin F*, Wen XB*. Identification of antioxidant peptides after digestion and absorption of isinglass by serum peptidomics and cellular antioxidant activity analysis. Food & Function. 2023, DOI: https://doi.org/10.1039/d2fo03847a.

5. Lin F^#, Zhang HR^#, Yu J, Yu CQ, Chen CY, Sun ZJ, Wang SQ, Wen XB*. Effects of dietary selenium on growth performance, antioxidative status and tissue selenium deposition of juvenile Chu's croaker (Nibea coibor). Aquaculture. 2021, 536: 736439.  

6. Lin F^#, Rong H^#, Lin JL, Yuan YY, Yu J, Yu CQ, You CH, Wang SQ, Sun ZJ, Wen XB*. Enhancement of collagen deposition in swim bladder of Chu's croaker (Nibea coibor) by proline: View from in-vitro and in-vivo study. Aquaculture. 2020, 523: 735175.

7. Lin JL, Shi X, Fang SB, Zhang Y, You CH, Ma HY*, Lin F*. Comparative transcriptome analysis combining SMRT and NGS sequencing provides novel insights into sex differentiation and development in mud crab (Scylla paramamosain). Aquaculture. 2019, 513:734447.

8. Xiao LF^#, Liang YJ^#, Ye XK, Zhang HR, Lv JH, Dong H, Lin F*, Wen XB*. Serum proteomic analysis reveals possible mechanism underlying physiological hemostasis of swim bladder. Journal of Proteomics. 2022, 266: 104668.

9. Guo HJ, Liu X, Tian MD, Liu GQ, Yuan YY, Ye XK, Zhang HR, Xiao LF, Wang SQ, Hong YC, Sun KH, Lin F*, Wen XB*. Effects of dietary collagen cofactors and hydroxyproline on the growth performance, textural properties and collagen deposition in swim bladder of Nibea coibor based on orthogonal array analysis. Aquaculture Reports, 2022, 27: 101375.

10. Lin F*, Liu X, Guo HJ, Liu GQ, Ye XK, Yuan YY, Lin JL, Wang SQ, Wen XB*. Sexual dimorphism in the texture properties of swim bladder of Nibea coibor and its molecular basis revealed by comparative transcriptome analysis. Aquaculture Reports. 2022, 25: 101207.

11. Lin F*, Ye XK, Lin JL, Liu X, Yuan YY, Guo HJ, Liu GQ, Wen XB*. Comparative transcriptome analysis between muscle and swim bladder reveals key genes regulating collagen deposition in zebrafish. Aquaculture Reports. 2022, 23: 101053.

12. Lin F^#,*, Lin JL^#, Liu X, Yuan YY, Liu GQ, Ye XK. Effects of temperature on muscle growth and collagen deposition in zebrafish (Danio rerio). Aquaculture Reports. 2022, 22: 100952.

13. Lin F^#, Dong L^#, Wang WM, Liu YC, Huang WR*, Cai ZM*. An efficient light-inducible P53 expression system for inhibiting proliferation of bladder cancer cell. International Journal of Biological Sciences. 2016, 12(10): 1273-1278.

14. Dong L^#, Lin F^#, Wu WJ, Huang WR*, Cai ZM*. Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell. Journal of Cancer. 2016, 7(14): 2132-2138.

15. Lin F, Liu QZ, Yuan YM, Hong YH*. Development of retroviral vectors for insertional mutagenesis in medaka haploid cells. Gene. 2015, 573(2): 296-302.

16. Lin F, Zhao CY, Xu SH, Ma DY, Xiao ZZ, Xiao YS, Xu CA, Liu QH*, Li J*. Germline-specific and sexually dimorphic expression of a dead end gene homologue in turbot (Scophthalmus maximus). Theriogenology. 2013, 80(6): 665-672.

17. Lin F^#, Liu QH^#, Li MY, Li ZD, Hong N, Li J*, Hong YH*. Transient and stable GFP expression in germ cells by the vasa regulatory sequences from the red seabream (Pagrus major). International Journal of Biological Sciences. 2012, 8(6): 882-890.

18. Lin F, Xu SH, Ma DY, Xiao ZZ, Zhao CY, Xiao YS, Chi L, Liu QH*, Li J*. Germ line specific expression of a vasa homologue gene in turbot (Scophthalmus maximus): evidence for vasa localization at cleavage furrows in euteleostei. Molecular Reproduction and Development. 2012, 79(11): 803-813.

19. 林帆, 刘清华, 李军*, 隋娟, 肖志忠, 徐世宏, 马道远, 肖永双. 真鲷 (Pagrus major) vasa基因5′端启动子克隆及表达载体构建. 海洋与湖沼. 2011, 42(02): 186-192.

     

• 发明专利：

1. 林帆，刘鑫，田梦都，郭浩棘，陈翠英，王树启，陈兆云。一种低鱼粉并改善浅色黄姑鱼鱼鳔质地的配合饲料，申请号：2022107528060 （实质审查）

2. 林帆，袁钰莹，林佳丽，余俊，郭浩棘，张浩然，王树启。一种浅色黄姑鱼鱼鳔细胞系的建立方法及应用，专利号：ZL202111406175.9 （授权）

3. 林帆，刘国权，郭浩棘，刘鑫，王树启，陈翠英。 一种含绿原酸的饲料及其制备方法和应用，申请号：202111479715.6 （实质审查）

4. 林帆，刘国权，刘鑫，郭浩棘，王树启，陈翠英。 一种含蚕豆水提物的饲料及其制备方法和应用，专利号：ZL202111473287.6 （授权）

5. 林帆，张俊源，欧俊杰，盛芊艾，周雨晴，黄泽宁。 一种斑马鱼肌肉特异诱导型表达载体及应用，专利号：ZL202011340788.2 （授权）

6. 刘清华，李军，林帆，徐世宏。一种大菱鲆胚胎发育期原始生殖细胞(PGCs)的定位标记方法，专利号：ZL201310274379.0 （授权）

7. 黄卫人，蔡志明，林帆。一种高效调控肿瘤细胞表型的光控基因表达装置，专利号：ZL201610795393.9 （授权）

8. 陈松林，崔忠凯，郑汉其，刘云，王娜，林帆，王文文，张宁，董钟典，李仰真。一种基于基因组编辑的海水鲆鲽鱼类种质构建方法及应用，专利号：ZL201610162019.5 （授权)

  标准：

1. 林帆，董慧，李艳芬，李春晓. 赤嘴鳘鱼胶加工技术规程. 汕头市地方标准. DB4405/T304-2023.

2.  林帆，黄芳，吴建荣，纪瑞喜，董慧，吴静勉等. 赤嘴鳘（双棘原黄姑鱼）鱼胶质量等级, T/STBZ 9-2021（团体标准）