学历简介:
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主要研究兴趣:
长期从事水产经济动物脂类营养饲料与代谢调控方面的研究,重点关注海水鱼类和青蟹高不饱和脂肪酸合成与转运调控机制。
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3个代表性项目:
(1)国家自然科学基金青年基金项目,31702357,miR-145在黄斑蓝子鱼HUFA合成调控中的作用及机制研究,2018/01-2020/12,26万元,结题,主持。
(2)中国博士后科学基金第60批资助项目,2016M602500,蓝子鱼LC-PUFA合成关键miRNAs的筛选及其调控机制研究,2016.04-2018.04,5万元,结题,主持。
(3)广东省科技专项资金“大专项+任务清单”( STKJ2021106):青蟹高效配合饲料的研发,2021-10-1至2024-9-30,10万元,在研,主持。
代表性发表论文:
(1) Chen, C.Y., Wang, S.Q., Hu, Y., Zhang, M., He, X.D., You, C.H., Wen, X.B., Monroig, Ó., Tocher, D.R., Li, Y.Y. miR-26a mediates LC-PUFA biosynthesis by targeting the Lxrα-Srebp1 pathway in the marine teleost Siganus canaliculatus, Journal of Biological Chemistry, 2020, 295:13875–13886.
(2) Chen, C.Y., Zhang, M., Li, Y.Y., Wang, S.Q., Xie, D.Z., Wen, X.B., Hu, Y., Shen, J.J., He, X.D., You, C.H., Tocher, D.R., Monroig, Ó. Identification of miR-145 as a key regulator involved in LC-PUFA biosynthesis by targeting hnf4α in the marine teleost Siganus canaliculatus. Journal of Agricultural and Food Chemistry, 2020, 68: 15123–15133.
(3) Chen, C.Y., Wang, S.Q., Zhang, M., Chen, B.J., You, C.H., Xie, D.Z., Liu, Y., Monroig, Ó., Tocher, D.R., Waiho. K., Li, Y.Y. miR-24 is involved in vertebrate LC-PUFA biosynthesis as demonstrated in marine teleost Siganus canaliculatus. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019, 1864(5): 619.
(4) Chen, C.Y., Zhang, J.Y., Zhang, M., You, C.H., Liu, Y., Wang, S.Q., Li, Y.Y. miR-146a is involved in the regulation of vertebrate LC-PUFA biosynthesis by targeting elovl5 as demonstrated in rabbitfish Siganus canaliculatus. Gene, 2018, 676: 306-314.
(5) Chen, C.Y., Guan, W.T., Xie, Q.M., Chen, G.L., He, X.L., Zhang, H.L., Guo, W.Y., Chen, F., Tan, Y.W., Pan, Q. n-3 essential fatty acids in Nile tilapia, Oreochromis niloticus: Bioconverting LNA to DHA is relatively efficient and LC-PUFA biosynthetic pathway is substrate limited in juvenile fish. Aquaculture, 2018, 495: 513-522.
(6) Chen, C.Y., Chen, J.H., Wang, S.Q., You, C.H., Li, Y.Y. Effects of different dietary ratios of linolenic to linoleic acids or docosahexaenoic to eicosapentaenoic acids on the growth and immune indices in grouper, Epinephelus coioides. Aquaculture, 2017, 473: 153-160.
(7) Chen, C.Y., Sun, B.L., Guan, W.T., Bi, Y.Z., Li, P.Y., Ma, J.Y., Chen, F., Pan, Q., Xie, Q.M. N-3 essential fatty acids in Nile tilapia, Oreochromis niloticus: Effects of linolenic acid on non-specific immunity and anti-inflammatory responses in juvenile fish. Aquaculture, 2016, 450: 250-257.
(8) Chen, C.Y., Sun, B.L., Li, X.X., Li, P.Y., Guan, W.T., Bi, Y.Z., Pan, Q. N-3 essential fatty acids in Nile tilapia, Oreochromis niloticus: Quantification of optimum requirement of dietary linolenic acid in juvenile fish. Aquaculture, 2013, 416-417: 99-104.
(9) Zhang, M.#, Chen, C.Y.#, You, C.H., Chen, B.J., Wang, S.Q.*, Li, Y.Y.* Effects of different dietary ratios of docosahexaenoic to eicosapentaenoic acid (DHA/EPA) on the growth, non-specific immune indices, tissue fatty acid compositions and expression of genes related to LC-PUFA biosynthesis in juvenile golden pompano Trachinotus ovatus. Aquaculture, 2019, 505, 488-495.
(10) Guo, H.J.#, Chen, C.Y.#, Yan, X., Li, Y.Y., Wen, X.B., You, C.H., Monroig, O., Tocher, D.R., Wang, S.Q. Effects of different dietary oil sources on growth performance, antioxidant capacity and lipid deposition of juvenile golden pompano Trachinotus ovatus. Aquaculture, 2021, 530, 735923.
(11) Liu, L.J. #, Chen, C.Y. #, Dong, Y.W., Cheng, Y., You, C.H., Wang, S.Q., Ma, H.Y., Li, Y.Y. Insulin activates LC-PUFA biosynthesis of hepatocytes by regulating the PI3K/Akt/mTOR/Srebp1 pathway in teleost Siganus canaliculatus. Comparative Biochemistry and Physiology, Part B, 2022, 260: 110734.