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行政—教辅—博士后


张薄博 [ 教授 ] 生物系 管理个人简历


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E-mail:bbzhang@stu.edu.cn

学历简介:
   
博士 2008-8 至 2011-12 香港中文大学
硕士 2005-9 至 2008-7 华南理工大学
学士 2001-9 至 2005-7 华南理工大学

工作经历:
   
2020-1 至 现在 汕头大学 理学院 生物系 教授
2012年1月 至 2019年12月 江南大学 生物工程学院 讲师-副教授
2014年6月 至 2016年1月 欧洲科学院苏宝连院士课题组 博士后

主要研究兴趣:    
主要从事微生物发酵,食品科学与生物医药方向的研究:(1)食药两用真菌发酵生产天然产物:红曲天然食用色素及降脂功能物质,牛樟芝、桑黄等药用真菌发酵合成药用活性物质,蘑菇多糖,中药发酵等;(2)益生菌相关研究及后生元在食品、保健品和医药领域的开发和应用;(3)海洋藻类活性物质在食品/化妆品中的应用。(4)食品废弃物的综合利用。

获奖情况:
   
2010 广东省优秀硕士论文
2010 IFT(美国食品科学学会)研究论文竞赛第二名
2012 第六届青年学术论坛优秀论文奖
2013 江南大学-至善青年学者
2016 欧盟FOTOBIOMAT项目优秀完成者
2017 扬州市“绿扬金凤计划” 优秀博士
2018 江苏省“双创计划”科技副总
2018 The 9th ICMBMP Excellent Presentation Award第九届世界食用菌生物学与产品大会杰出报告奖
2019 指导的研究生中有2位获得国家奖学金
2018 指导的研究生中有1位学生获得江苏省优秀硕士论文称号

承担项目:
   
[ 1 ] 国家重点研发计划-子课题(主持) 红曲黄色素的工业化生产及稳态化技术研究;(编号:2016YFD0400802),
[ 2 ] 国家自然科学基金-面上项目(主持)枯草芽孢杆菌和红曲菌共培养诱导天然黄色素合成的分子机制(编号 32072184)
[ 3 ] 国家自然科学基金-青年项目(主持)樟芝菌丝体安卓奎诺尔生物合成的调控机理研究(编号 21306065)
[ 4 ] 江苏省自然科学基金(主持) 樟芝特有活性物质Antroquinonol的分子合成及调控应答机制研究;(编号:BK20181348),
[ 5 ] 江苏省自然科学基金(主持) 基于蛋白质组学的樟芝液态发酵活性代谢产物的生物合成机制研究;(编号:BK20130134),

[ 6 ] 中央高校基本科研专项资金(主持) 液态发酵樟芝菌丝体高产活性多糖的研究;
[ 7 ] 北京市食品添加剂工程技术研究中心开放课题(主持)
[ 8 ] 企业横向合作项目(主持) 樟芝活性产物的检测、分析和纯品制备技术;
[ 9 ] 企业横向合作项目(主持) 红曲黄色素提取精制技术的研究开发;
[ 10 ] 横向-企业合作项目(主持)乳杆菌中抑菌物质的研究

研究成果:
   
[ 1 ] Bo-Bo Zhang*, Li Wang, Valérie Charles, Joanna C. Rooke, Bao-Lian Su*;Robust and biocompatible hybrid matrix with controllable permeability for microalgae encapsulation;ACS Applied Materials & Interfaces, 2016, 8: 8939–8946;
[ 2 ] Bo-Bo Zhang*, Yu-Yan Guan, Peng-Fei Hu, Lei Chen, Gan-Rong Xu, Liming Liu, Peter C.K. Cheung;Production of bioactive metabolites by submerged fermentation of the medicinal mushroom Antrodia cinnamomea: recent advances and future development;Critical Reviews in Biotechnology, 2019, 39, 541-554;
[ 3 ] Bo-Bo Zhang, Peter C K Cheung*;A mechanistic study of the enhancing effect of Tween 80 on the mycelial growth and exopolysaccharide production by Pleurotus tuber-regium;Bioresource Technology, 2011, 102: 8323–8326;
[ 4 ] Li Wang, Zhi-Yi Hu, Xiao-Yu Yang*, Bo-Bo Zhang*, Wei Geng, Gustaaf Van Tendelooce, Bao-Lian Su*;Polydopamine nanocoated whole-cell asymmetric biocatalyst;Chemical Communications, 2017, 53, 6617–6620;
[ 5 ] Peng-Fei Hu, Jing Huang, Lei Chen, Zhongyang Ding, Liming Liu, Istva?n Molna?r*, and Bo-Bo Zhang*;Oxidative stress induction is a rational strategy to enhance the productivity of Antrodia cinnamomea fermentations for the antioxidant secondary metabolite antrodin C;Journal of Agricultural and Food Chemistry, 2020, 68: 3995–4004;
[ 6 ] Bo-Bo Zhang*, Peng-Fei Hu, Jing Huang, Yong-Dan Hu, Lei Chen, Gan-Rong Xu;Current advances on the structure, bioactivity, synthesis and metabolic regulation of novel ubiquinone derivatives in the edible and medicinal mushroom Antrodia cinnamomea;Journal of Agricultural and Food Chemistry, 2017, 65, 10395–10405;
[ 7 ] Jun Lv, Gao-Fei Qian, Lei Chen, Huan Liu, Hai-Xiao Xu, Gan-Rong Xu, Bo-Bo Zhang*, Chan Zhang*;Efficient biosynthesis of natural yellow pigments by Monascus purpureus in a novel integrated fermentation system;Journal of Agricultural and Food Chemistry, 2018, 66: 918?925;
[ 8 ] Bo-Bo Zhang, Peter C K Cheung*;Use of stimulatory agents to enhance the production of bioactive exopolysaccharide from Pleurotus tuber-regium by submerged fermentation;Journal of Agricultural and Food Chemistry, 2011, 59: 1210-1216;
[ 9 ] Bo-Bo Zhang, Lei Chen, Peter C K Cheung*;Two-dimensional gel electrophoresis analysis of mycelial cells treated with Tween 80: Differentially expressed protein related to enhanced metabolite production;Journal of Agricultural and Food Chemistry, 2012, 60: 10585–10591;
[ 10 ] Bo-Bo Zhang, Jing Cheng, Wen-Yong Lou, Pan Wang, Min-Hua Zong*;Efficient anti-Prelog enantioselective reduction of acetyltrimethylsilane to (R)-1-trimethylsilylethanol by immobilized Candida parapsilosis CCTCC M203011 cells in ionic liquid-based biphasic systems;Microbial Cell Factories, 2012, 11: 108–120;
[ 11 ] Yong-Dan Hu, Bo-Bo Zhang*, Gan-Rong Xu, Xiang-Ru Liao*, Peter C.K. Cheung;A mechanistic study on the biosynthetic regulation of bioactive metabolite Antroquinonol from edible and medicinal mushroom Antrodia camphorata;Journal of Functional Foods, 2016, 25: 70–79;
[ 12 ] Yong-Dan Hu, Huan Zhang, Rui-Qiu Lu, Xiang-Ru Liao, Bo-Bo Zhang*, Gan-Rong Xu*;Enabling the biosynthesis of Antroquinonol in submerged fermentation of Antrodia camphorata;Biochemical Engineering Journal, 2014, 91: 157-162;
[ 13 ] Huan Zhang, Yong-Dan Hu, Rui-Qiu Lu, Yong-jun Xia, Bo-Bo Zhang*, Gan-Rong Xu*;Integrated strategy of pH?shift and glucose feeding for enhanced production of bioactive Antrodin C in submerged fermentation of Antrodia camphorata;Journal of Industrial Microbiology & Biotechnology, 2014, 41: 1305–1310;
[ 14 ] Bo-Bo Zhang, Li-Ping Lu, Gan-Rong Xu*;Why solid-state fermentation is more advantageous over submerged fermentation for converting high concentration of glycerol into Monacolin K by Monascus purpureus 9901: A mechanistic study;Journal of Biotechnology, 2015, 206, 60–65;
[ 15 ] Jun Lv, Bo-Bo Zhang*, Xiao-Dong Liu, Chan Zhang, Lei Chen, Gan-Rong Xu, Peter C.K. Cheung;Enhanced production of natural yellow pigments from Monascus purpureus by liquid culture: The relationship between fermentation conditions and mycelial morphology;Journal of Bioscience and Bioengineering, 2017, 124, 452–458;